Hemodynamic arterial changes in heart failure. a proposed new paradigm of heart and vessels failure. The Copernican revolution?

Abstract Background Although heart failure (HF) is one of the most common conditions affecting heart, little attention has been placed on role arteries in contributing to progression this disease. Purpose We sought determine hemodynamic change HF patients subdivided according left ventricular ejection fraction. The major goal was establish active compensatory Methods Using sphygmography, we systematically studied a cohort 228 and 52 healthy controls. focused carotid as main elastic artery posterior tibial muscular (Figure 1). Moreover, categorized three groups, HFrEF, HFmrEF, HFpEF, into two subgroups (A B) presence or absence signs at baseline. Results discovered that all parameters measured arterial kinetics, i.e., work, power, acceleration, speed, were significantly increased (p<0.001 by one-way ANOVA) groups without signs. In contrast, kinetics reduced (p<0.001) exhibiting Similar results obtained both types consistently observed across different HF, although with some differences magnitude. Finally, HFpEF exhibited more compromised function vis-à-vis HFrEF 2: Patients Disposition (Top) Quantification (Down) from [A] [B]). Conclusions provide first documentation an during HF. Mechanistically, explain these findings dual activity large accomplished via propulsive work concurrent suction. These underestimated functions partially compensate for dysfunction underlining key interplay between vessels. propose new paradigm define “heart vessels failure” explicitly focuses vessels' interaction Funding Acknowledgement Type funding sources: None. Figure 1. Sphygmograms CCA PTAFigure 2. disposition &